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Focus on Autism and Other Developmental Disabilities
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Article

Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings

Vladimir Trajkovski, Aleksandar Petlichkovski, Olivija Efinska-Mladenovska, Dejan Trajkov, Todor Arsov, Ana Strezova, Ljubomir Ajdinski, and Mirko Spiroski*

* To whom correspondence should be addressed. E-mail: mspiroski{at}yahoo.com.


  Abstract
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder. Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.

First published on July 16, 2008, doi:10.1177/1088357608320413

Focus on Autism and Other Developmental Disabilities 2008;23:176.

A more recent version of this article appeared on September 1, 2008

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